Human MMP-8/Neutrophil collagenase ELISA Kit PicoKine®

SKU: EK0464

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: MMP8

Specificity: Natural and recombinant human total MMP-8

Background: Matrix metalloproteinase 8 (MMP8) also called neutrophil collagenase. Neutrophil collagenase, a member of the family of matrix metalloproteinases, is distinct from the collagenase of skin fibroblasts and synovial cells in substrate specificity and immunologic crossreactivity. MMP8, an enzyme that degrades fibrillar collagens imparting strength to the fetal membranes, is expressed by leukocytes and chorionic cytotrophoblast cells. The human neutrophil collagenase (HNC) cDNA clone has been sequenced and shown to encode a 467-residue protein. Neutrophil collagenase has been found to possess 57% identity with the deduced protein sequence for fibroblast collagenase with 72% chemical similarity. Certain regions of the molecule, including the putative zinc-binding region, are highly conserved. When compared with the published sequence for fibroblast collagenase, neutrophil collagenase contains four additional sites for glycosylation. The standard product used in this kit is natural, isolating from human MMP-8. The detected MMP-8 includes zymogen and active enzyme.

Immunogen: Expression system for standard: NS0; Immunogen sequence: F21-G467

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Uniprot ID: P22894

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 4317

Protein Name: Neutrophil collagenase

Gene Full Name: matrix metallopeptidase 8

Synonyms: CLG1; HNC; Matrix metalloproteinase 8; MMP 8; MMP8; Neutrophil collagenase; PMNL CL; PMNL collagenase