Human MMP-3 PicoKine® Quick ELISA Kit

SKU: FEK0461

Size: 96 wells/kit, with removable strips.

Storage: Store at 4°C for 6 months. (Ships with gel ice, can store for up to 3 days in room temperature. Refrigerate upon receipt.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: CST3

Specificity: Natural and recombinant Human MMP3

Background: Matrix metalloproteinase-3 (MMP-3) also called stromelysin or transin, is a proteoglycanase closely related to collagenase (MMP1) with a wide range of substrate specificities. The complete primary structure for human MMP-3, which has 477 residues including a 17-residue signal peptide. MMP-3 and collagenase are 54% identical in sequence, suggesting a common origin for the evolution of the two proteinases. MMP-3 and collagenase expression are coordinately modulated in synovial fibroblast cultures. MMP-3 is a secreted metalloprotease produced predominantly by connective tissue cells. Together with other metalloproteases, it can synergistically degrade the major components of the extracellular matrix. It is capable of degrading proteoglycan, fibronectin, laminin, and type IV collagen, but not interstitial type I collagen. MMP-3 genotype may be an important determinant of vascular remodeling and age-related arterial stiffening, with the heterozygote having the optimal balance between matrix accumulation and deposition. The standard product used in this kit is recombinant human MMP-3, consisting of 460 amino acids with the molecular mass of 52KDa. The detected MMP-3 includes zymogen and active enzyme.

Immunogen: Expression system for standard: NS0; Immunogen sequence: Y18-C477

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Uniprot ID: P08254

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 4314

Protein Name: Stromelysin-1

Gene Full Name: matrix metallopeptidase 3

Synonyms: CHDS6; Matrix metalloproteinase 3; MMP 3; MMP3; SL 1; STMY; STMY1; STR1; Stromelysin 1; Transin 1