Human Minichromosome Maintenance Deficient 2,MCM2 ELISA KIT

SKU: E7142Hu

Size:96 Tests-1 Kit

Background:Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis. {ECO:0000269|PubMed:26196677, ECO:0000269|PubMed:8175912}.

Research_area:

Applications:ELISA

Target_protein:MCM2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.28ng/ml

Detection range:0.5-150ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Minichromosome Maintenance Deficient 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P49736

MASS(Da):101896

GeneID:4171

Synonyms:MCM2 BM28 CCNL1 CDCL1 KIAA0030

Gene names:MCM2

Standard solution:160ng/ml