Human MIA ELISA Kit PicoKine®

SKU: EK0941

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: MIA

Specificity: Natural and recombinant human MIA

Background: Melanoma Inhibiting Activity (MIA), also known as cartilage-derived retinoic acid-sensitive protein (CD-RAP), is an approximately 11-15 kDa protein that is expressed as a noncovalent homodimer. MIA is structurally related to OTOR/Otoraplin and MIA-2 in a small family of secreted proteins with one SH3 domain (1-3). And the MIA gene was mapped to 19q13.32-q13.33 by fluorescence in situ hybridization. Beside, It is a marker for malignant melanoma. MIA functions as a chemoattractant for mesenchymal stem cells and enhances their BMP-2 and TGF-beta3 induced differentiation into chondrocytes . MIA-deficient mice exhibit delayed chondrocyte differentiation but enhanced chondrocyte proliferation and cartilage repair .

Immunogen: Expression system for standard: E.coli; Immunogen sequence: G25-131Q

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Reference:

Uniprot ID: Q16674

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 8190

Protein Name: Melanoma-derived growth regulatory protein

Gene Full Name: MIA SH3 domain containing

Synonyms: CD RAP; melanoma inhibitory activity; MIA