Human Matrix Metalloproteinase 13, MMP13 ELISA Kit

SKU: E0911Hu

Size:96 Tests-1 Kit

Background:Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.

Research_area:Cardiovascular; Signal Transduction; Cancer

Applications:ELISA

Target_protein:MMP13

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.04ng/ml

Detection range:0.1-30ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Matrix Metalloproteinase 13

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P45452

MASS(Da):53,820

GeneID:4322

Synonyms:Collagenase 3;Matrix Metalloproteinase-13;MMP 13;MMP13;MMP-13

Gene names:MMP13

Standard solution:32ng/ml