Human Low molecular mass protein 7,LMP7 ELISA KIT

SKU: E2027Hu

Size:96 Tests-1 Kit

Background:The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119). Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes. {ECO:0000269|PubMed:16423992, ECO:0000269|PubMed:19443843, ECO:0000269|PubMed:21881205, ECO:0000269|PubMed:27049119, ECO:0000269|PubMed:8163024}.

Research_area:

Applications:ELISA

Target_protein:PSMB8

Reactivity:Human

Assay type:Sandwich

Sensitivity:22.68ng/L

Detection range:50-3200ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:low molecular-weight protein;proteasome beta-type subunit

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P28062

MASS(Da):30354

GeneID:5696

Synonyms:PSMB8 LMP7 PSMB5i RING10 Y2

Gene names:PSMB8

Standard solution:6400ng/L