Human Leukocyte Elastase Inhibitor, LEI ELISA Kit

SKU: E2231Hu

Size:96 Tests-1 Kit

Background:Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed: 30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed: 11747453, PubMed: 30692621). Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed: 23269243). During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed: 30692621). When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed: 26701651).

Research_area:Cell Biology

Applications:ELISA

Target_protein:SERPINB1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.057ng/ml

Detection range:0.1-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Leukocyte Elastase Inhibitor

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P30740

MASS(Da):42,742

GeneID:1992

Synonyms:EI;LEI;Leukocyte elastase inhibitor;M/NEI;Monocyte/neutrophil elastase inhibitor;Peptidase inhibitor 2;PI-2;Serpin B1;SERPINB 1;SERPINB1

Gene names:SERPINB1

Standard solution:48ng/ml