Human Leucine-rich Repeat-containing G-protein Coupled Receptor 5, LGR5 ELISA Kit

SKU: E5569Hu

Size:96 Tests-1 Kit

Background:Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:LGR5

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.49ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 5

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O75473

MASS(Da):99,998

GeneID:8549

Synonyms:G-protein coupled receptor 49;G-protein coupled receptor 67;G-protein coupled receptor HG38;Leucine-rich repeat-containing G-protein coupled receptor 5;LGR 5;LGR5

Gene names:LGR5

Standard solution:2400ng/L