Human Latent-Transforming Growth Factor Beta-binding Protein 1, LTBP1 ELISA Kit

SKU: E4040hu

Size:96 Tests-1 Kit

Background:Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:LTBP1

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.41ng/L

Detection range:10-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Latent-transforming growth factor beta-binding protein 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q14766

MASS(Da):186,796

GeneID:4052

Synonyms:ARCL2E;Latent-transforming growth factor beta-binding protein 1;LTBP1;LTBP-1;TGF-beta1-BP-1;Transforming growth factor beta-1-binding protein 1

Gene names:LTBP1

Standard solution:3200ng/L