Human Large tumor suppressor homolog 1,LATS1 ELISA KIT

SKU: E4673Hu

Size:96 Tests-1 Kit

Background:Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cell differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668). {ECO:0000269|PubMed:10518011, ECO:0000269|PubMed:10831611, ECO:0000269|PubMed:15122335, ECO:0000269|PubMed:15220930, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:28068668}.

Research_area:

Applications:ELISA

Target_protein:LATS1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.044ng/ml

Detection range:0.1-38ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Large tumor suppressor homolog 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O95835

MASS(Da):126870

GeneID:9113

Synonyms:LATS1 WARTS

Gene names:LATS1

Standard solution:40ng/ml