Human Klotho, KL ELISA Kit

SKU: E2781Hu

Size:96 Tests-1 Kit

Background:May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). The Klotho Peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.

Research_area:Developmental Biology

Applications:ELISA

Target_protein:KL

Reactivity:Human

Assay type:Sandwich

Sensitivity:2.47pg/ml

Detection range:5-1000pg/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Klotho

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9UEF7

MASS(Da):116,181

GeneID:9365

Synonyms:KL;Klotho;Klotho Peptide

Gene names:KL

Standard solution:1280pg/ml