Human Killer cell lectin-like receptor subfamily B member 1,KLRB1 ELISA KIT

SKU: E6901Hu

Size:96 Tests-1 Kit

Background:Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. {ECO:0000269|PubMed:16455998, ECO:0000269|PubMed:16925668, ECO:0000269|PubMed:8077657}.

Research_area:

Applications:ELISA

Target_protein:KLRB1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.13ng/ml

Detection range:0.25-16ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:CD161

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q12918

MASS(Da):25415

GeneID:3820

Synonyms:KLRB1 CLEC5B NKRP1A

Gene names:KLRB1

Standard solution:32ng/ml