Human killer cell immunoglobulin-like receptor,KIR2DL4 ELISA KIT

SKU: E7337Hu

Size:96 Tests-1 Kit

Background:Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:16366734). Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent proinflammatory response (PubMed:20179272). {ECO:0000269|PubMed:10190900, ECO:0000269|PubMed:16366734, ECO:0000269|PubMed:20179272, ECO:0000269|PubMed:23184984, ECO:0000269|PubMed:29262349}.

Research_area:

Applications:ELISA

Target_protein:KIR2DL4

Reactivity:Human

Assay type:Sandwich

Sensitivity:11.54ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:killer cell immunoglobulin-like receptor

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q99706

MASS(Da):41487

GeneID:3805

Synonyms:KIR2DL4 CD158D KIR103AS

Gene names:KIR2DL4

Standard solution:6400ng/L