Human Interleukin 11, IL-11 ELISA Kit

SKU: E0101Hu

Size:96 Tests-1 Kit

Background:Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed: 2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed: 12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed: 30279168).

Research_area:Immunology

Applications:ELISA

Target_protein:IL11

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.31ng/L

Detection range:0.5-300ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interleukin 11

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P20809

MASS(Da):21,429

GeneID:3589

Synonyms:Adipogenesis inhibitory factor;AGIF;IL 11;IL11;IL-11;Interleukin-11;Oprelvekin

Gene names:IL11

Standard solution:320ng/L