Human Interleukin-10 Receptor Subunit Alpha, IL10RA ELISA Kit

SKU: E6471Hu

Size:96 Tests-1 Kit

Background:Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed: 16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed: 12133952). These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (PubMed: 26962683).

Research_area:Immunology

Applications:ELISA

Target_protein:IL10RA

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.023ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Interleukin-10 Receptor Subunit Alpha

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q13651

MASS(Da):63,003

GeneID:3587

Synonyms:CD antigen CD210;CDw210a;IL 10RA;IL-10 receptor subunit alpha;IL-10R subunit 1;IL-10R subunit alpha;IL-10R1;IL10RA;IL-10RA;Interleukin-10 receptor subunit 1;Interleukin-10 receptor subunit alpha

Gene names:IL10RA

Standard solution:24ng/ml