Human Interferon Regulatory Factor 9, IRF9 ELISA Kit

SKU: E2760Hu

Size:96 Tests-1 Kit

Background:Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Research_area:Immunology

Applications:ELISA

Target_protein:IRF9

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.58ng/L

Detection range:20-3800ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interferon Regulatory Factor 9

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q00978

MASS(Da):43,696

GeneID:10379

Synonyms:IFN-alpha-responsive transcription factor subunit;Interferon regulatory factor 9;Interferon-stimulated gene factor 3 gamma;IRF 9;IRF9;IRF-9;ISGF-3 gamma;ISGF3 p48 subunit;Transcriptional regulator ISGF3 subunit gamma;

Gene names:IRF9

Standard solution:4000ng/L