Human Interferon alpha;beta receptor 1,IFNAR1 ELISA KIT

SKU: E0306Hu

Size:96 Tests-1 Kit

Background:Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986, PubMed:32972995). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). {ECO:0000250|UniProtKB:P33896, ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:15337770, ECO:0000269|PubMed:19561067, ECO:0000269|PubMed:2153461, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:7665574, ECO:0000305|PubMed:21854986}.

Research_area:

Applications:ELISA

Target_protein:IFNAR1

Reactivity:Human

Assay type:Sandwich

Sensitivity:3.16ng/L

Detection range:7-1500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interferon α;β Receptor

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P17181

MASS(Da):63525

GeneID:3454

Synonyms:IFNAR1 IFNAR

Gene names:IFNAR1

Standard solution:1600ng/L