Human Insulin Receptor Substrate 4, IRS-4 ELISA Kit

SKU: E3128Hu

Size:96 Tests-1 Kit

Background:Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:IRS4

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.091ng/ml

Detection range:0.2-70ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Insulin Receptor Substrate 4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O14654

MASS(Da):133,768

GeneID:8471

Synonyms:160 kDa phosphotyrosine protein;Insulin receptor substrate 4;IRS 4;IRS4;IRS-4;Phosphoprotein of 160 kDa;pp160;py160

Gene names:IRS4

Standard solution:80ng/ml