Human IL-33 PicoKine® Quick ELISA Kit

SKU: FEK0929

Size: 96 wells/kit, with removable strips.

Storage: Store at 4°C for 6 months. (Ships with gel ice, can store for up to 3 days in room temperature. Refrigerate upon receipt.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: IL33

Specificity: Natural and recombinant human IL-33

Background: Interleukin 33 (IL-33) is a cytokine belonging to the IL-1 superfamily. The IL33 gene maps to chromosome 9p24.1 by using of genomic database analysis. Recombinant mature human IL33 bound to ST2. The induction of type 2 cytokines by IL-33 in vivo is believed to induce the severe pathological changes observed in mucosal organs following administration of IL-33. IL33, an alarmin released from necrotic cells, is necessary for potent CD8 + T cell (CTL) responses to replicating, prototypic RNA, and DNA viruses in mice. IL33 prevented the downregulation of CXCR2 and inhibition of chemotaxis induced by activation of TLR4, and found that IL33 reverses the TLR4-induced reduction of CXCR2 expression via the inhibition of expression of GRK2.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: S112-T270

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Uniprot ID: O95760

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 90865

Protein Name: Interleukin-33

Gene Full Name: interleukin 33

Synonyms: C9orf26; DVS27; IL 1F11; IL 33; IL1F11; IL33; IL-33; Interleukin 1 family member 11; interleukin 33; NF HEV; NFEHEV; NFHEV; RP11 575C20.2