Human Histone Deacetylase 4, HDAC4 ELISA Kit

SKU: E5410Hu

Size:96 Tests-1 Kit

Background:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed: 27708256).

Research_area:Others

Applications:ELISA

Target_protein:HDAC4

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.48ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Histone Deacetylase 4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P56524

MASS(Da):119,040

GeneID:9759

Synonyms:HD4;HDAC 4;HDAC4;Histone deacetylase 4

Gene names:HDAC4

Standard solution:4800ng/L