Human Histone Deacetylase 2, HDAC2 ELISA Kit

SKU: E2025Hu

Size:96 Tests-1 Kit

Background:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.

Research_area:Others

Applications:ELISA

Target_protein:HDAC2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.031ng/ml

Detection range:0.05-30ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Histone Deacetylase 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q92769

MASS(Da):55,364

GeneID:3066

Synonyms:HD2;HDAC 2;HDAC2;Histone deacetylase 2

Gene names:HDAC2

Standard solution:32ng/ml