Human Hepatocyte Growth Factor Receptor, c-MET ELISA Kit

SKU: E5392Hu

Size:96 Tests-1 Kit

Background:Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity). (Microbial infection) Acts as a receptor for Listeria monocytogenes internalin InlB, mediating entry of the pathogen into cells.

Research_area:Cancer

Applications:ELISA

Target_protein:MET

Reactivity:Human

Assay type:Sandwich

Sensitivity:10.02ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Hepatocyte Growth Factor Receptor

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P08581

MASS(Da):155,541

GeneID:4233

Synonyms:Hepatocyte growth factor receptor;HGF receptor;HGF/SF receptor;MET;Proto-oncogene c-Met;Scatter factor receptor;SF receptor;Tyrosine-protein kinase Met

Gene names:MET

Standard solution:4800ng/L