Human Glutaredoxin-2, Mitochondrial, GLRX2 ELISA Kit

SKU: E5342Hu

Size:96 Tests-1 Kit

Background:Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.

Research_area:Others

Applications:ELISA

Target_protein:GLRX2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.52ng/L

Detection range:1-400ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Glutaredoxin-2, Mitochondrial

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NS18

MASS(Da):18,052

GeneID:51022

Synonyms:GLRX 2;GLRX2;Glutaredoxin-2, mitochondrial

Gene names:GLRX2

Standard solution:480ng/L