Human Glutamate[NMDA]receptor subunit epsilon-2,GRIN2B ELISA KIT

SKU: E4453Hu

Size:96 Tests-1 Kit

Background:Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735, PubMed:26875626). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q01097, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:8768735}.

Research_area:

Applications:ELISA

Target_protein:GRIN2B

Reactivity:Human

Assay type:Sandwich

Sensitivity:1.53ng/L

Detection range:3-900ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Glutamate[NMDA]receptor subunit epsilon-2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q13224

MASS(Da):166367

GeneID:2904

Synonyms:GRIN2B NMDAR2B

Gene names:GRIN2B

Standard solution:960ng/L