Human GFRA2 ELISA Kit PicoKine®

SKU: EK2072

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: GFRA2

Specificity: Natural and recombinant human GFRA2

Background: GDNF family receptor alpha-2 (GFRα2), also known as the neurturin receptor, is a protein that in humans is encoded by the GFRA2 gene. It is mapped to 8p21.3. The GFRA2 protein is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. They both bind the GFRA2 receptor. The receptor mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. GFRA2 (gene) has been shown to interact with GDNF.

Immunogen: Expression system for standard: NS0; Immunogen sequence: S22-S444

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Uniprot ID: O00451

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 2675

Protein Name: GDNF family receptor alpha-2

Gene Full Name: GDNF family receptor alpha 2

Synonyms: GDNF family receptor alpha 2; GDNF receptor alpha 2; GDNF receptor beta; GDNFR alpha 2; GDNFR beta; GDNFRB; GFR alpha 2; GFRA2; Neurturin receptor alpha; NRTNR ALPHA; NTNR alpha; NTNRA; RET ligand 2; RETL2; TRNR2