Human Gamma-secretase Subunit Aph-1A, APH1A ELISA Kit

SKU: E5319Hu

Size:96 Tests-1 Kit

Background:Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed: 12297508, PubMed: 12522139, PubMed: 12763021, PubMed: 12679784, PubMed: 25043039, PubMed: 26280335, PubMed: 30598546, PubMed: 30630874). Required for normal gamma-secretase assembly (PubMed: 12522139, PubMed: 12471034, PubMed: 12763021, PubMed: 19369254). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).

Research_area:Others

Applications:ELISA

Target_protein:APH1A

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.32ng/L

Detection range:20-3800ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Gamma-Secretase Subunit Aph-1A

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q96BI3

MASS(Da):28,996

GeneID:51107

Synonyms:APH1A;APH-1a;Aph-1alpha;Gamma-secretase subunit APH-1A;Presenilin-stabilization factor

Gene names:APH1A

Standard solution:4000ng/L