Human Gamma-secretase Activating Protein, GSAP ELISA Kit

SKU: E3675Hu

Size:96 Tests-1 Kit

Background:Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate amyloid-beta, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.

Research_area:Others

Applications:ELISA

Target_protein:gSAP

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.023ng/ml

Detection range:0.05-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Gamma-Secretase Activating Protein

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:A4D1B5

MASS(Da):97,802

GeneID:54103

Synonyms:Gamma-secretase-activating protein;Gamma-secretase-activating protein 16 kDa C-terminal form;gSAP;GSAP-16K];PION;Protein pigeon homolog

Gene names:GSAP

Standard solution:48ng/ml