Human Gamma-aminobutyric Acid Type B Receptor Subunit 2, GABBR2 ELISA Kit

SKU: E6458Hu

Size:96 Tests-1 Kit

Background:Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed: 9872316, PubMed: 9872744, PubMed: 15617512, PubMed: 18165688, PubMed: 22660477, PubMed: 24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed: 18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed: 10075644, PubMed: 10773016, PubMed: 24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium Channels, inactivates voltage-dependent calcium-Channels and modulates inositol phospholipid hydrolysis (PubMed: 10075644, PubMed: 9872744, PubMed: 10906333, PubMed: 10773016). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed: 9872744, PubMed: 22660477). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium Channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed: 9872316, PubMed: 10075644, PubMed: 9872744, PubMed: 22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable).

Research_area:Others

Applications:ELISA

Target_protein:GABBR2

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.63ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Gamma-Aminobutyric Acid Type B Receptor Subunit 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O75899

MASS(Da):105,821

GeneID:9568

Synonyms:GABA-B receptor 2;GABABR2;GABA-BR2;GABA-B-R2;GABBR 2;GABBR2;Gamma-aminobutyric acid type B receptor subunit 2;Gb2;G-protein coupled receptor 51;HG20

Gene names:GABBR2

Standard solution:2400ng/L