Human G1;S-specific Cyclin-D1,CCND1 ELISA KIT

SKU: E3586Hu

Size:96 Tests-1 Kit

Background:Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. {ECO:0000269|PubMed:15241418, ECO:0000269|PubMed:16569215, ECO:0000269|PubMed:18417529, ECO:0000269|PubMed:9106657}.

Research_area:

Applications:ELISA

Target_protein:CCND1

Reactivity:Human

Assay type:Sandwich

Sensitivity:12.46ng/L

Detection range:25-1600ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cyclin D1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P24385

MASS(Da):33729

GeneID:595

Synonyms:CCND1 BCL1 PRAD1

Gene names:CCND1

Standard solution:3200ng/L