Human Frizzled-1, FZD1 ELISA Kit

SKU: E2368Hu

Size:96 Tests-1 Kit

Background:Receptor for Wnt proteins (PubMed: 10557084). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed: 10557084). Contradictory results showing activation by WNT7B have been described for mouse (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed: 10557084). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed: 10557084). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium.

Research_area:Others

Applications:ELISA

Target_protein:FZD1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.03ng/ml

Detection range:0.05-30ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Frizzled-1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9UP38

MASS(Da):71,158

GeneID:8321

Synonyms:Frizzled-1;Fz-1;FZD 1;FZD1;FzE1;hFz1

Gene names:FZD1

Standard solution:32ng/ml