Human Fermitin Family Homolog 2, FERM2 ELISA Kit

SKU: E3652Hu

Size:96 Tests-1 Kit

Background:Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.

Research_area:Others

Applications:ELISA

Target_protein:FERMT2

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.026ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Fermitin Family Homolog 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q96AC1

MASS(Da):77,861

GeneID:10979

Synonyms:Fermitin family homolog 2;FERMT 2;FERMT2;Kindlin-2;MIG-2;Mitogen-inducible gene 2 protein;PH domain-containing family C member 1;Pleckstrin homology domain-containing family C member 1

Gene names:FERMT2

Standard solution:24ng/ml