Human F7 ELISA Kit PicoKine®

SKU: EK2197

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: F7

Specificity: Natural and recombinant human F7

Background: Coagulation factor VII (EC 3.4.21.21, formerly known as proconvertin) is one of the proteins that causes blood to clot in the coagulation cascade, and in humans is coded for by the gene F7. This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.

Immunogen: Expression system for standard: NS0; Immunogen sequence: A39-P444

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Reference:

Uniprot ID: P08709

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 2155

Protein Name: Coagulation factor VII

Gene Full Name: coagulation factor VII

Synonyms: Coagulation factor VII; Eptacog alfa; F7; Proconvertin; SPCA