Human ERBB3/Her3 ELISA Kit PicoKine®

SKU: EK1398

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: ERBB3

Specificity: Natural and recombinant human ERBB3

Background: Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene. ErbB3 has been shown to bind the ligands heregulin and NRG-2. Ligand binding causes a change in conformation that allows for dimerization, phosphorylation, and activation of signal transduction. ErbB3 can heterodimerize with any of the other three ErbB family members. The theoretical ErbB3 homodimer would be non-functional because the kinase-impaired protein requires transphosporylation by its binding partner to be active. Unlike the other ErbB receptor tyrosine kinase family members which are activated through autophosphorylation upon ligand binding, ErbB3 is found to be kinase impaired, having only 1/1000th the autophosphorylation activity of EGFR and no ability to phosphorylate other proteins. Therefore, ErbB3 must act as anallosteric activator.

Immunogen: Expression system for standard: NS0; Immunogen sequence: S20-T643

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Reference:

Uniprot ID: P21860

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 2065

Protein Name: Receptor tyrosine-protein kinase erbB-3

Gene Full Name: erb-b2 receptor tyrosine kinase 3

Synonyms: c erbB 3; c erbB3; ErbB 3; ERBB3; erbB3 S; HER3; LCCS2; MDA BF 1; p180 ErbB3; p45 sErbB3; p85 sErbB3