Human Endothelin 3, ET3 ELISA Kit

SKU: E3205Hu

Size:96 Tests-1 Kit

Background:Endothelin-3 is a protein that in humans is encoded by the EDN3 gene. The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.

Research_area:Others

Applications:ELISA

Target_protein:ET-3

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.29ng/L

Detection range:0.5-200ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Endothelin 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P14138

MASS(Da):25,454

GeneID:1908

Synonyms:Endothelin-3;ET3;ET-3;HSCR4;PPET3;Preproendothelin-3;WS4B

Gene names:EDN3

Standard solution:240ng/L