Human DNA Replication Licensing Factor Mcm7, MCM7 ELISA Kit

SKU: E5193Hu

Size:96 Tests-1 Kit

Background:Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:MCM7

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.31ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Dna Replication Licensing Factor MCM7

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P33993

MASS(Da):81,308

GeneID:4176

Synonyms:CDC47 homolog;DNA replication licensing factor MCM7;MCM 7;MCM7;P1.1-MCM3

Gene names:MCM7

Standard solution:3200ng/L