Human DNA Repair Protein RAD50, RAD50 ELISA Kit

SKU: E4019hu

Size:96 Tests-1 Kit

Background:Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:RAD50

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.04ng/ml

Detection range:0.1-50ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:DNA Repair Protein RAD50

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q92878

MASS(Da):153,892

GeneID:10111

Synonyms:DNA repair protein RAD50;hRad50;NBSLD;RAD50;RAD502

Gene names:RAD50

Standard solution:56ng/ml