Human DKK-3 PicoKine® Quick ELISA Kit

SKU: FEK1323

Size: 96 wells/kit, with removable strips.

Storage: Store at 4°C for 6 months. (Ships with gel ice, can store for up to 3 days in room temperature. Refrigerate upon receipt.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: DKK3

Specificity: Natural and recombinant Human DDK3

Background: Dickkopf-related protein 3 is a protein that in humans is encoded by the DKK3 gene. This gene encodes a protein that is a member of the dickkopf family. It is mapped to 11p15.3. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Members of the Dkk-related family display unique patterns of mRNA expression in human and mouse tissues, and are secreted when expressed in 293T cells. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Immunogen: Expression system for standard: NS0; Immunogen sequence: A22-I350

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Reference:

Uniprot ID: Q9UBP4

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 27122

Protein Name: Dickkopf-related protein 3

Gene Full Name: dickkopf Wnt signaling pathway inhibitor 3

Synonyms: Dickkopf 3; Dickkopf related protein 3; Dkk 3; DKK3; hDkk 3; REIC; RIG