Human Defensin Beta 126,DEFb126 ELISA KIT

SKU: E3147Hu

Size:96 Tests-1 Kit

Background:Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface components and allows sperm to penetrate the cumulus matrix and bind to the zona pellucida of the oocyte (By similarity). In vitro has antimicrobial activity and may inhibit LPS-mediated inflammation (PubMed:19373462, PubMed:23229569). {ECO:0000250|UniProtKB:Q9BEE3, ECO:0000269|PubMed:19373462, ECO:0000269|PubMed:23229569}.

Research_area:

Applications:ELISA

Target_protein:DEFB126

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.1ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Defensin Beta 126

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9BYW3

MASS(Da):12174

GeneID:81623

Synonyms:DEFB126 C20orf8 DEFB26

Gene names:DEFB126

Standard solution:24ng/ml