Human Cytochrome P450 26A1, CYP26A1 ELISA Kit

SKU: E5159Hu

Size:96 Tests-1 Kit

Background:A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 and C-18. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomers (PubMed: 22020119, PubMed: 9228017, PubMed: 9716180). May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (PubMed: 26937021).

Research_area:Others

Applications:ELISA

Target_protein:CYP26A1

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.9ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cytochrome P450 26A1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O43174

MASS(Da):56,199

GeneID:1592

Synonyms:CYP26A1;Cytochrome P450 26A1;Cytochrome P450 retinoic acid-inactivating 1;Cytochrome P450RAI;hP450RAI;Retinoic acid 4-hydroxylase;Retinoic acid-metabolizing cytochrome

Gene names:CYP26A1

Standard solution:2400ng/L