Human Cytochrome Coxidase Subunit 6C, COX6C ELISA Kit

SKU: E6758Hu

Size:96 Tests-1 Kit

Background:Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP Synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Research_area:Tags & Cell Markers

Applications:ELISA

Target_protein:COX6C

Reactivity:Human

Assay type:Sandwich

Sensitivity:13.68ng/L

Detection range:20-7000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cytochrome C Oxidase Subunit 6C

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P09669

MASS(Da):8,781

GeneID:1345

Synonyms:COX6C;Cytochrome c oxidase polypeptide VIc;Cytochrome c oxidase subunit 6C

Gene names:COX6C

Standard solution:8000ng/L