Human Cytochrome B-C1 Complex Subunit 2, UQCRC2 ELISA Kit

SKU: E6753Hu

Size:96 Tests-1 Kit

Background:Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (By similarity). The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties (By similarity). May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable).

Research_area:Signal Transduction; Cancer; Metabolism

Applications:ELISA

Target_protein:UQCRC2

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.1ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cytochrome b-c1 complex subunit 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P22695

MASS(Da):48,443

GeneID:7385

Synonyms:Complex III subunit 2;Core protein II;Cytochrome b-c1 complex subunit 2, mitochondrial;MC3DN5;QCR2;Ubiquinol-cytochrome-c reductase complex core protein 2;UQCR2;UQCRC2

Gene names:UQCRC2

Standard solution:2400ng/L