Human Coxsackievirus and Adenovirus Receptor, CXADR ELISA Kit

SKU: E5123Hu

Size:96 Tests-1 Kit

Background:Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. (Microbial infection) Acts as a receptor for adenovirus type C. (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6.

Research_area:Microbiology

Applications:ELISA

Target_protein:CXADR

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.092ng/ml

Detection range:0.2-60ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Coxsackievirus and adenovirus receptor

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P78310

MASS(Da):40,030

GeneID:1525

Synonyms:CAR;CAR4/6;Coxsackievirus and adenovirus receptor;Coxsackievirus B-adenovirus receptor;CVB3-binding protein;CXADR;HCAR;HCVADR

Gene names:CXADR

Standard solution:64ng/ml