Human Condensin-2 Complex Subunit D3, NCAPD3 ELISA Kit

SKU: E5116Hu

Size:96 Tests-1 Kit

Background:Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).

Research_area:Cell Biology

Applications:ELISA

Target_protein:NCAPD3

Reactivity:Human

Assay type:Sandwich

Sensitivity:7.35ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Condensin-2 complex subunit D3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P42695

MASS(Da):168,891

GeneID:23310

Synonyms:CAPD3;CAP-D3;Condensin-2 complex subunit D3;hCAP-D3;hcp-6;hHCP-6;MCPH22;NCAPD3;Non-SMC condensin II complex subunit D3;

Gene names:NCAPD3

Standard solution:3200ng/L