Human Complement fragment C4b,C4b ELISA KIT

SKU: E0371Hu

Size:96 Tests-1 Kit

Background:Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.; Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Research_area:

Applications:ELISA

Target_protein:C4B; C4B_2

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.24ng/L

Detection range:10-3800ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Complement fragment 4b

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P0C0L5

MASS(Da):192751

GeneID:100293534

Synonyms:C4B CO4 CPAMD3; C4B_2

Gene names:C4B; C4B_2

Standard solution:4000ng/L