Human cluster of differentiation 45,CD45 ELISA KIT

SKU: E5054Hu

Size:96 Tests-1 Kit

Background:Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:2845400}.; (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. {ECO:0000269|PubMed:22174689}.

Research_area:

Applications:ELISA

Target_protein:PTPRC

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.024ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:cluster of differentiation 45

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P08575

MASS(Da):147486

GeneID:5788

Synonyms:PTPRC CD45

Gene names:PTPRC

Standard solution:24ng/ml