Human cleaved Caspase 3,CASP3 ELISA KIT

SKU: E6970Hu

Size:96 Tests-1 Kit

Background:Involved in the activation cascade of caspases responsible for apoptosis execution (PubMed:7596430). At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond (PubMed:7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (PubMed:7596430). Involved in the cleavage of huntingtin (PubMed:8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed:21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:23152800). {ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:23152800, ECO:0000269|PubMed:7596430, ECO:0000269|PubMed:7774019, ECO:0000269|PubMed:8696339}.

Research_area:

Applications:ELISA

Target_protein:CASP3

Reactivity:Human

Assay type:Sandwich

Sensitivity:8.06ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:cleaved Caspase 3

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P42574

MASS(Da):31608

GeneID:836

Synonyms:CASP3 CPP32

Gene names:CASP3

Standard solution:3200ng/L