Human Claspin, CLSPN ELISA Kit

SKU: E2899Hu

Size:96 Tests-1 Kit

Background:Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:CLSPN

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.026ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Claspin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9HAW4

MASS(Da):151,094

GeneID:63967

Synonyms:Claspin;CLSPN;hClaspin

Gene names:CLSPN

Standard solution:24ng/ml