Human Chondroitin Sulfate Proteoglycan 4, CSPG4 ELISA Kit

SKU: E5043Hu

Size:96 Tests-1 Kit

Background:Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.

Research_area:Cardiovascular

Applications:ELISA

Target_protein:CSPG4

Reactivity:Human

Assay type:Sandwich

Sensitivity:6.91ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Chondroitin Sulfate Proteoglycan 4

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q6UVK1

MASS(Da):250,537

GeneID:1464

Synonyms:Chondroitin sulfate proteoglycan 4;Chondroitin sulfate proteoglycan NG2;CSPG 4;CSPG4;Melanoma chondroitin sulfate proteoglycan;Melanoma-associated chondroitin sulfate proteoglycan

Gene names:CSPG4

Standard solution:3200ng/L