Human CD5L/CT-2 PicoKine® Quick ELISA Kit

SKU: FEK1413

Size: 96 wells/kit, with removable strips.

Storage: Store at 4°C for 6 months. (Ships with gel ice, can store for up to 3 days in room temperature. Refrigerate upon receipt.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: CD5L

Specificity: Natural and recombinant human CD5L

Background: CD5 antigen-like, also known as Sp alpha and AIM, is a protein that in humans is encoded by the CD5L gene. It is mapped to 1q21-q23 by fluorescence in situ hybridization. It is found that Aim expression is induced in mouse macrophages in response to loading with highly oxidized low density lipoprotein (oxLDL), and that Aim is expressed in foam cells within atherosclerotic lesions. Both the expression of Aim in lesions and its induction by oxLDL require Lxr /Rxr heterodimers. Aim-null macrophages are highly susceptible to oxLDL-induced apoptosis in vitro and undergo accelerated apoptosis in atherosclerotic lesions in vivo. Double knockout of Aim and Ldlr reduce atherosclerotic lesions. Therefore, it is concluded that AIM expression protects macrophages from apoptosis within atherosclerotic lesions, promoting early lesion development.

Immunogen: Expression system for standard: NS0; Immunogen sequence: S20-G347

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Reference:

Uniprot ID: O43866

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 922

Protein Name: CD5 antigen-like

Gene Full Name: CD5 molecule like

Synonyms: AIM; API6; CD5 antigen like; CD5 molecule like; CD5L; CT 2; IgM associated peptide; PRO229; SP ALPHA; Spalpha