Human Caspase 10,CASP10 ELISA KIT

SKU: E2249Hu

Size:96 Tests-1 Kit

Background:Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. {ECO:0000269|PubMed:11717445}.; Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. {ECO:0000269|PubMed:17822854}.; Isoform C is proteolytically inactive. {ECO:0000269|PubMed:11717445}.

Research_area:

Applications:ELISA

Target_protein:CASP10

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.21ng/ml

Detection range:0.38-24ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Caspase 10

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q92851

MASS(Da):58951

GeneID:843

Synonyms:CASP10 MCH4

Gene names:CASP10

Standard solution:48ng/ml